fatigue
fa-tigue
noun
Extreme tiredness resulting from mental or physical exertion, illness, or lack of sleep.
"She felt overwhelming fatigue after the long journey."
verb
To cause someone to become extremely tired or worn out.
"The demanding work will fatigue anyone quickly."
Thesaurus
Synonyms: tire, weary, jade, pall, wear, wear out, tire out, outwear, fag out, fag, wear upon, wear down